Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774

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dc.contributor.authorAyla, Sule
dc.contributor.authorBilir, Ayhan
dc.contributor.authorErturkoglu, Senol
dc.contributor.authorTanriverdi, Gamze
dc.contributor.authorSoner, B. Cem
dc.contributor.authorSofuoglu, Kenan
dc.contributor.authorGhisolfi, Laura
dc.contributor.authorOktem, Gulperi
dc.date.accessioned2019-10-27T10:46:09Z
dc.date.available2019-10-27T10:46:09Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single and combined applications in monolayers of the MDAH-2774 human ovarian cancer cell line. Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dye exclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h. Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cell cultures (P < 0.05). All combination groups showed similar effects that were mainly more effective in respect to single usage of resveratrol and gemcitabine in monolayer cell cultures. Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 human ovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction of cell structure were observed.en_US
dc.identifier.doi10.3906/sag-1507-193
dc.identifier.endpage448en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid29714468en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1507-193
dc.identifier.urihttps://hdl.handle.net/11454/31258
dc.identifier.volume48en_US
dc.identifier.wosWOS:000431261100036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvarian canceren_US
dc.subjectgemcitabineen_US
dc.subjectparacetamolen_US
dc.subjectresveratrolen_US
dc.titleEffects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774en_US
dc.typeArticleen_US

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