Interleukin-1 receptor antagonist and tumour necrosis factor-alpha gene polymorphisms in Turkish patients with allergic contact dermatitis

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dc.contributor.authorErtam, Ilgen
dc.contributor.authorItirli, Gulcin
dc.contributor.authorOnay, Huseyin
dc.contributor.authorAlper, Sibel
dc.contributor.authorÖzkınay, Ferda
dc.date.accessioned2019-10-27T20:20:05Z
dc.date.available2019-10-27T20:20:05Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground It has been shown that the family of interleukin-1 receptor antagonist (IL-1 RA) and tumour necrosis factor-alpha (TNF alpha) genes are polymorphic and related to some inflammatory diseases. Allergic contact dermatitis is the classic presentation of delayed-type hypersensitivity responses to exogenous agents. A number of genes playing role in inflammatory response may be associated with allergic contact dermatitis. Objectives To investigate whether there is an association between IL-1RA and TNF alpha gene polymorphisms and allergic contact dermatitis in Turkish patients with allergic contact dermatitis. Methods This study was performed by the collaboration of Departments of Dermatology and Medical Genetics, Ege University, Faculty of Medicine. A total of 50 patients (31 females and 19 males) with allergic contact dermatitis, and 100 age- and sex-matched controls (58 females and 42 males) were included in the study. IL-1RA Variable Number of Tandem Repeats (VNTR) polymorphism in intron 2 and TNF alpha-308G-A polymorphism were genotyped by using polymerase chain reaction and agarose gel electrophoresis. Results The frequency of IL-1RA 1/2 (48%) genotype was significantly higher (P = 0.002) in patient group than that is found in control group (22%). The frequency of TNF alpha (TNF G-308A) G/G genotype was significantly higher in patient group (68%) than that is found in control group (31%) (P = 0.008). Conclusions Our findings suggest that TNF alpha (G/G) gene polymorphism may play role in susceptibility to allergic contact dermatitis in Turkish patients.en_US
dc.identifier.doi10.1111/j.1600-0536.2009.01593.xen_US
dc.identifier.endpage90en_US
dc.identifier.issn0105-1873
dc.identifier.issue2en_US
dc.identifier.pmid19706048en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0536.2009.01593.x
dc.identifier.urihttps://hdl.handle.net/11454/41565
dc.identifier.volume61en_US
dc.identifier.wosWOS:000269182800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofContact Dermatitisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectallergic contact dermatitisen_US
dc.subjectgenesen_US
dc.subjectinterleukin-1RAen_US
dc.subjectTNF alphaen_US
dc.titleInterleukin-1 receptor antagonist and tumour necrosis factor-alpha gene polymorphisms in Turkish patients with allergic contact dermatitisen_US
dc.typeArticleen_US

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