Interleukin-1 receptor antagonist and tumour necrosis factor-alpha gene polymorphisms in Turkish patients with allergic contact dermatitis
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell Publishing, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background It has been shown that the family of interleukin-1 receptor antagonist (IL-1 RA) and tumour necrosis factor-alpha (TNF alpha) genes are polymorphic and related to some inflammatory diseases. Allergic contact dermatitis is the classic presentation of delayed-type hypersensitivity responses to exogenous agents. A number of genes playing role in inflammatory response may be associated with allergic contact dermatitis. Objectives To investigate whether there is an association between IL-1RA and TNF alpha gene polymorphisms and allergic contact dermatitis in Turkish patients with allergic contact dermatitis. Methods This study was performed by the collaboration of Departments of Dermatology and Medical Genetics, Ege University, Faculty of Medicine. A total of 50 patients (31 females and 19 males) with allergic contact dermatitis, and 100 age- and sex-matched controls (58 females and 42 males) were included in the study. IL-1RA Variable Number of Tandem Repeats (VNTR) polymorphism in intron 2 and TNF alpha-308G-A polymorphism were genotyped by using polymerase chain reaction and agarose gel electrophoresis. Results The frequency of IL-1RA 1/2 (48%) genotype was significantly higher (P = 0.002) in patient group than that is found in control group (22%). The frequency of TNF alpha (TNF G-308A) G/G genotype was significantly higher in patient group (68%) than that is found in control group (31%) (P = 0.008). Conclusions Our findings suggest that TNF alpha (G/G) gene polymorphism may play role in susceptibility to allergic contact dermatitis in Turkish patients.
Açıklama
Anahtar Kelimeler
allergic contact dermatitis, genes, interleukin-1RA, TNF alpha
Kaynak
Contact Dermatitis
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
61
Sayı
2
