Effects of selected antibiotics on pancreatitis induced liver and pulmonary injury

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dc.contributor.authorÖnek T.
dc.contributor.authorErkan N.
dc.contributor.authorZeytunlu M.
dc.contributor.authorSagol Ö.
dc.contributor.authorÇoker C.
dc.contributor.authorÇoker A.
dc.date.accessioned2019-10-27T00:11:56Z
dc.date.available2019-10-27T00:11:56Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the protective effect of antibiotherapy in the early phase of acute pancreatitis on cellular injury induced in lungs and liver. BACKGROUND: Cellular viability and plasma nitric oxide (NO) levels were assessed to determine the efficacy of highly bactericidal imipenem and quinolones on liver and lung injury. METHODS: Imipenem, levofloxacin or saline were administered to rats with caerulein induced pancreatitis. Twenty-four hours later serum amylase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and NO levels, pancreatic interstitial inflammation, acinar cell necrosis, acinar cell vacuolisation, peripancreatic fat necrosis; spotty necrosis, focal inflammation of liver and inflammatory processes in the lungs were assessed. RESULTS: Enzyme levels in the antibiotherapy groups were lower than in the control group. Serum NO levels were higher only in the imipenem group. Levofloxacin decreased acinar cell vacuolisation in the pancreas; interstitial edema, neutrophilic infiltration and interstitial enlargement in the lungs. Antibiotherapy decreased spotty necrosis, apoptosis and focal inflammation in the liver. CONCLUSIONS: Although treatment with imipenem is associated with higher NO levels than levofloxacin, levofloxacin prevents organ injury more effectively than imipenem in acute pancreatitis. Our results indicate that antibiotherapy in the early period of necrotizing pancreatitis prevents cellular damage induced in pancreas, liver and lungs.en_US
dc.identifier.endpage10en_US
dc.identifier.issn1300-6738
dc.identifier.issue1en_US
dc.identifier.pmid15688261en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://hdl.handle.net/11454/22260
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImipenemen_US
dc.subjectLevofloxacinen_US
dc.subjectLiveren_US
dc.subjectLungsen_US
dc.subjectNOen_US
dc.subjectPancreatitisen_US
dc.titleEffects of selected antibiotics on pancreatitis induced liver and pulmonary injuryen_US
dc.typeArticleen_US

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