Evaluation of the Brain Cellular Damage during Liver Transplantations

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dc.authorscopusid57198208230
dc.authorscopusid58550608600
dc.authorscopusid24831289600
dc.authorscopusid56197950800
dc.contributor.authorDeniz, M. N.
dc.contributor.authorSezer, E.
dc.contributor.authorTetik, A.
dc.contributor.authorUlukaya, S.
dc.date.accessioned2024-08-25T18:38:50Z
dc.date.available2024-08-25T18:38:50Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground:Neuroinflammation in patients undergoing major surgery can lead to neuronal damage, and neuronal damage can be detected through the measurement of biochemical markers of brain damage. S100 beta (S100 & beta;), neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) levels are considered good biomarkers to detect brain damage that emerged with neurotoxicity. Aim:To evaluate neuronal damage during liver transplantations. Materials and Methods:After approval of the ethics committee and patient consents, preoperative and postoperative cognitive functions of 33 patients undergoing liver transplantation were measured using the Mini Mental State Examination (MMSE), whereas simultaneous neuronal damage was evaluated through the measurement of S100 & beta;, NSE, and GFAP levels. Results:There was no statistically significant difference between preoperative and postoperative MMSE. There was a statistically significant decrease in postoperative GFAP (P < 0.05) and a statistically significant increase in NSE (P < 0.05) compared to preoperative values. The decrease in S100 & beta; (P > 0.05) level was statistically insignificant. Conclusions:Neuroprotective approaches in anesthesia protocol protect patients from brain damage during liver transplantation and prevent the development of postoperative cognitive dysfunction. Since the significant increase in NSE levels during liver transplantations was deemed to have been associated with causes other than neuronal damage, NSE should not be evaluated as a marker of brain damage in these operations.en_US
dc.description.sponsorshipEge University Scientific Research Project Izmir, Turkey [18-TIP-026]en_US
dc.description.sponsorship& nbsp;This work was supported by the Ege University Scientific Research Project Izmir, Turkey. Funding Number: 18-TIP-026.en_US
dc.identifier.doi10.4103/njcp.njcp_332_22
dc.identifier.endpage1068en_US
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue8en_US
dc.identifier.pmid37635597en_US
dc.identifier.scopus2-s2.0-85168843121en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1063en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_332_22
dc.identifier.urihttps://hdl.handle.net/11454/101164
dc.identifier.volume26en_US
dc.identifier.wosWOS:001050229900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBrainen_US
dc.subjectLiver transplantationen_US
dc.subjectNeuron-specific enolase and glial fibrillary acidic proteinen_US
dc.subjectNeuronal damageen_US
dc.subjectS100 beta proteinen_US
dc.subjectPostoperative Cognitive Dysfunctionen_US
dc.subjectNeuron-Specific Enolaseen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectProteinen_US
dc.subjectNeuroinflammationen_US
dc.subjectInjuryen_US
dc.subjectSerumen_US
dc.subjectAssociationen_US
dc.subjectAnesthesiaen_US
dc.titleEvaluation of the Brain Cellular Damage during Liver Transplantationsen_US
dc.typeArticleen_US

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