Evaluation of the Brain Cellular Damage during Liver Transplantations
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background:Neuroinflammation in patients undergoing major surgery can lead to neuronal damage, and neuronal damage can be detected through the measurement of biochemical markers of brain damage. S100 beta (S100 & beta;), neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) levels are considered good biomarkers to detect brain damage that emerged with neurotoxicity. Aim:To evaluate neuronal damage during liver transplantations. Materials and Methods:After approval of the ethics committee and patient consents, preoperative and postoperative cognitive functions of 33 patients undergoing liver transplantation were measured using the Mini Mental State Examination (MMSE), whereas simultaneous neuronal damage was evaluated through the measurement of S100 & beta;, NSE, and GFAP levels. Results:There was no statistically significant difference between preoperative and postoperative MMSE. There was a statistically significant decrease in postoperative GFAP (P < 0.05) and a statistically significant increase in NSE (P < 0.05) compared to preoperative values. The decrease in S100 & beta; (P > 0.05) level was statistically insignificant. Conclusions:Neuroprotective approaches in anesthesia protocol protect patients from brain damage during liver transplantation and prevent the development of postoperative cognitive dysfunction. Since the significant increase in NSE levels during liver transplantations was deemed to have been associated with causes other than neuronal damage, NSE should not be evaluated as a marker of brain damage in these operations.
Açıklama
Anahtar Kelimeler
Brain, Liver transplantation, Neuron-specific enolase and glial fibrillary acidic protein, Neuronal damage, S100 beta protein, Postoperative Cognitive Dysfunction, Neuron-Specific Enolase, N-Acetylcysteine, Cardiac-Surgery, Protein, Neuroinflammation, Injury, Serum, Association, Anesthesia
Kaynak
Nigerian Journal of Clinical Practice
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
26
Sayı
8
