The Fc gamma RIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis

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dc.contributor.authorGulen, Figen
dc.contributor.authorTanac, Remziye
dc.contributor.authorAltinoz, Serdar
dc.contributor.authorBerdeli, Afig
dc.contributor.authorZeyrek, Dost
dc.contributor.authorKoksoy, Huseyin
dc.contributor.authorDemir, Esen
dc.date.accessioned2019-10-27T19:35:45Z
dc.date.available2019-10-27T19:35:45Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to evaluate the Fc gamma RIIa polymorphism in Turkish children with atopic asthma and allergic rhinitis. Design and methods: In this study, 372 atopic children (192 asthma bronchial, 180 allergic rhinitis) between ages of 5 and 16 years old (11.3 +/- 2.9) who were followed at Aegean University Paediatric Allergy and Pulmonology Outpatient Clinics and 234 healthy subjects as the control group were included. The evaluation of subjects included routine biochemical blood analysis and allergic workup based on the following laboratory determinants. The Fc gamma RIIa polymorphism was determined using the polymerase chain reaction method. Results: Distribution of RI 3 1 R genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 2.64 95%CI: 1.22-5.79, p=0.006; for allergic rhinitis OR: 2.58 95%CI: 1.18-5.71, p=0.009). Frequency of 131R allele was significantly different among patient groups compared to controls (for asthmatic children OR: 1.66 95%CI: 1.22-2.26, p=0.0007; for allergic rhinitis OR: 1.93 95%CI: 1.42-2.63, p=0.00001). Conclusion: This study shows that Fc gamma RIIa gene 131R allele represents an important genetic risk factor for bronchial asthma and allergic rhinitis susceptibility. (c) 2007 Published by The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2006.11.014en_US
dc.identifier.endpage396en_US
dc.identifier.issn0009-9120
dc.identifier.issue05.Junen_US
dc.identifier.pmid17291475en_US
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2006.11.014
dc.identifier.urihttps://hdl.handle.net/11454/39772
dc.identifier.volume40en_US
dc.identifier.wosWOS:000244997400019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFc gamma RIIa geneen_US
dc.subjectpolymorphismen_US
dc.subjectallergic rhinitisen_US
dc.subjectasthma bronchialen_US
dc.subjectchildrenen_US
dc.titleThe Fc gamma RIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitisen_US
dc.typeArticleen_US

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