The Fc gamma RIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of the present study was to evaluate the Fc gamma RIIa polymorphism in Turkish children with atopic asthma and allergic rhinitis. Design and methods: In this study, 372 atopic children (192 asthma bronchial, 180 allergic rhinitis) between ages of 5 and 16 years old (11.3 +/- 2.9) who were followed at Aegean University Paediatric Allergy and Pulmonology Outpatient Clinics and 234 healthy subjects as the control group were included. The evaluation of subjects included routine biochemical blood analysis and allergic workup based on the following laboratory determinants. The Fc gamma RIIa polymorphism was determined using the polymerase chain reaction method. Results: Distribution of RI 3 1 R genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 2.64 95%CI: 1.22-5.79, p=0.006; for allergic rhinitis OR: 2.58 95%CI: 1.18-5.71, p=0.009). Frequency of 131R allele was significantly different among patient groups compared to controls (for asthmatic children OR: 1.66 95%CI: 1.22-2.26, p=0.0007; for allergic rhinitis OR: 1.93 95%CI: 1.42-2.63, p=0.00001). Conclusion: This study shows that Fc gamma RIIa gene 131R allele represents an important genetic risk factor for bronchial asthma and allergic rhinitis susceptibility. (c) 2007 Published by The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Fc gamma RIIa gene, polymorphism, allergic rhinitis, asthma bronchial, children
Kaynak
Clinical Biochemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
40
Sayı
05.Jun
