Effects of adrenalectomy on CART expression in the rat arcuate nucleus

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dc.contributor.authorBalkan, B
dc.contributor.authorKoylu, E
dc.contributor.authorPogun, S
dc.contributor.authorKuhar, MJ
dc.date.accessioned2019-10-27T18:38:30Z
dc.date.available2019-10-27T18:38:30Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractIn order to test for glucocorticoid regulation of CART in the arcuate nucleus, adrenalectomies (ADX) and hormone replacements (HRs) were carried out in groups of rats. CART mRNA levels were determined by in situ hybridization and CART peptide levels by immunocytochemistry. ADX caused a lowering of CART mRNA and peptides levels in the arcuate and this was reversed by HR. These results indicate a glucocorticoid regulation of CART in the arcuate. The regulation could be direct through an action of glucocorticoid receptors or indirectly through ADX-induced changes in leptin levels. These findings suggest a role for CART in the stress response. (C) 2003 Wiley-Liss, Inc.en_US
dc.description.sponsorshipNCRR NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [RR00165]; NIDA NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) [DA 00418, DA 10732]en_US
dc.identifier.doi10.1002/syn.10213en_US
dc.identifier.endpage19en_US
dc.identifier.issn0887-4476
dc.identifier.issue1en_US
dc.identifier.pmid12872289en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://doi.org/10.1002/syn.10213
dc.identifier.urihttps://hdl.handle.net/11454/36608
dc.identifier.volume50en_US
dc.identifier.wosWOS:000184888100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofSynapseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCART peptideen_US
dc.subjectadrenalectomyen_US
dc.subjectarcuate nucleusen_US
dc.subjectleptinen_US
dc.subjectstressen_US
dc.titleEffects of adrenalectomy on CART expression in the rat arcuate nucleusen_US
dc.typeArticleen_US

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