Effects of adrenalectomy on CART expression in the rat arcuate nucleus
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Liss
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In order to test for glucocorticoid regulation of CART in the arcuate nucleus, adrenalectomies (ADX) and hormone replacements (HRs) were carried out in groups of rats. CART mRNA levels were determined by in situ hybridization and CART peptide levels by immunocytochemistry. ADX caused a lowering of CART mRNA and peptides levels in the arcuate and this was reversed by HR. These results indicate a glucocorticoid regulation of CART in the arcuate. The regulation could be direct through an action of glucocorticoid receptors or indirectly through ADX-induced changes in leptin levels. These findings suggest a role for CART in the stress response. (C) 2003 Wiley-Liss, Inc.
Açıklama
Anahtar Kelimeler
CART peptide, adrenalectomy, arcuate nucleus, leptin, stress
Kaynak
Synapse
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
50
Sayı
1
