Increased thickness of the carotid artery intima-media assessed by ultrasonography in Behcet's disease

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dc.contributor.authorKeser, G
dc.contributor.authorAksu, K
dc.contributor.authorTamsel, S
dc.contributor.authorOzmen, M
dc.contributor.authorKitapcioglu, G
dc.contributor.authorKabaroglu, C
dc.contributor.authorKilli, R
dc.contributor.authorBayindir, O
dc.contributor.authorDoganavsargil, E
dc.date.accessioned2019-10-27T19:24:26Z
dc.date.available2019-10-27T19:24:26Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Behcet's disease (BD), is a unique systemic vasculitis, which affects almost all types and sizes of blood vessels. Carotid intima-media thickness (IMT) is an endothelial cell dysfunction (ECD) parameter which may also be associated with atherosclerosis. We aimed to search carotid IMT and plaque formation in BD, using high-resolution B-mode Doppler ultrasonography (USG). Methods. We studied 114 BD patients (M/F: 68146; mean age 38.15 +/- 9.44 years; disease duration 121 +/- 79 months), being followed tip by Ege University; Rheumatology Department. A e and sex-matched, 77 healthy, controls, and as the disease control group 46 non-matched SLE patients were also included. Exclusion criteria for all the study participants were, hypertension, hyperlipidemia, diabetes mellitus, obesity and history of cardiovascular or cerebrovascular disease. Comparison of the three groups were made by ANOVA and for post-hoc confirmation, Bonferoni test was used. Results. The carotid IMT in BD (mean +/- SD, 0.55 +/- 0.14 min) was significantly higher than in healthy controls (0.48 +/- 0.09 min) (p = 0.004), but signficantly lower than in SLE (0.66 +/- 0.24 mm) (p = 0.001). Likewise, plaque frequency in BD (5/114) was significantly higher than in health), controls (0/77), but significantly lower than in SLE (8146) (p < 0.001). Conclusion. Despite significantly higher carotid IMT and plaque frequency in BD compared with healthy controls, these parameters in BD were not as marked as in SLE. Less severe carotid artery abnormalities in BD, may partially explain why cardiovascular morbidity and mortality do not seem to be increased in BD, unlike in SLE.en_US
dc.identifier.endpageS76en_US
dc.identifier.issn0392-856X
dc.identifier.issue4en_US
dc.identifier.pmid16273769en_US
dc.identifier.startpageS71en_US
dc.identifier.urihttps://hdl.handle.net/11454/39273
dc.identifier.volume23en_US
dc.identifier.wosWOS:000233017000015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinical & Exper Rheumatologyen_US
dc.relation.ispartofClinical and Experimental Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectatherosclerosisen_US
dc.subjectDoppler ultrasounden_US
dc.titleIncreased thickness of the carotid artery intima-media assessed by ultrasonography in Behcet's diseaseen_US
dc.typeArticleen_US

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