Increased thickness of the carotid artery intima-media assessed by ultrasonography in Behcet's disease
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clinical & Exper Rheumatology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective. Behcet's disease (BD), is a unique systemic vasculitis, which affects almost all types and sizes of blood vessels. Carotid intima-media thickness (IMT) is an endothelial cell dysfunction (ECD) parameter which may also be associated with atherosclerosis. We aimed to search carotid IMT and plaque formation in BD, using high-resolution B-mode Doppler ultrasonography (USG). Methods. We studied 114 BD patients (M/F: 68146; mean age 38.15 +/- 9.44 years; disease duration 121 +/- 79 months), being followed tip by Ege University; Rheumatology Department. A e and sex-matched, 77 healthy, controls, and as the disease control group 46 non-matched SLE patients were also included. Exclusion criteria for all the study participants were, hypertension, hyperlipidemia, diabetes mellitus, obesity and history of cardiovascular or cerebrovascular disease. Comparison of the three groups were made by ANOVA and for post-hoc confirmation, Bonferoni test was used. Results. The carotid IMT in BD (mean +/- SD, 0.55 +/- 0.14 min) was significantly higher than in healthy controls (0.48 +/- 0.09 min) (p = 0.004), but signficantly lower than in SLE (0.66 +/- 0.24 mm) (p = 0.001). Likewise, plaque frequency in BD (5/114) was significantly higher than in health), controls (0/77), but significantly lower than in SLE (8146) (p < 0.001). Conclusion. Despite significantly higher carotid IMT and plaque frequency in BD compared with healthy controls, these parameters in BD were not as marked as in SLE. Less severe carotid artery abnormalities in BD, may partially explain why cardiovascular morbidity and mortality do not seem to be increased in BD, unlike in SLE.
Açıklama
Anahtar Kelimeler
Behcet's disease, atherosclerosis, Doppler ultrasound
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
23
Sayı
4
