Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever

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dc.contributor.authorKütükçüler N.
dc.contributor.authorKaraca N.E.
dc.contributor.authorSözeri B.Y.
dc.contributor.authorKoturoglu G.
dc.contributor.authorKurugöl Z.
dc.contributor.authorÖzyürek R.A.
dc.contributor.authorAksu G.
dc.date.accessioned2019-10-26T23:58:00Z
dc.date.available2019-10-26T23:58:00Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytakines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with ARF at the time of admission and 3 months after treatment in order to evaluate changes in cytokine concentrations occurring during different stages of the disease. Methods: Serum concentrations of two anti-inflammatory cytokines, IL-I Re and sTNF-RI , were investigated in children with ARF atthe time of admission (n=21) and after 3 months following the cessation of treatment (n=15). The sTNF-RI and sIL-IRa were measured quantitatively in serum using enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1 Re and sTNF-RI were found to be significantly higher during acute phase and remission period of ARF when compared to age-matched healthy controls (p=0.001 and p=0.0001, respectively). Conclusion: Our study demonstrated that two anti-inflammatory cytokines, serum sTNFRI and IL-1 Ra, are increased in acute and remission stages of ARF reflecting activation of the cellular immune response. We suggest this increase might probably be generated in an effort to counteract the already increased concentrations of proinflammatory cytokines.en_US
dc.identifier.endpage142en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.pmid18400635en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/11454/21130
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute rheumatic feveren_US
dc.subjectInterleukin-1 receptor antagonisten_US
dc.subjectSoluble tumor necrosis factor receptor Ien_US
dc.titleHuman soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic feveren_US
dc.typeArticleen_US

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