Association of arms2 gene rs10490924 and htra1 gene rs11200638 polymorphisms with exudative age-related macular degeneration in western aegean population of turkey

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dc.authorscopusid35200763900
dc.authorscopusid6506820542
dc.authorscopusid7003907434
dc.authorscopusid6701353935
dc.authorscopusid56147066300
dc.authorscopusid6701589330
dc.authorscopusid6507248544
dc.contributor.authorHazan F.
dc.contributor.authorNalçaci S.
dc.contributor.authorAkin H.
dc.contributor.authorMenteş J.
dc.contributor.authorAfrashi F.
dc.contributor.authorErakgün T.
dc.contributor.authorItirli G.
dc.date.accessioned2023-01-12T20:26:13Z
dc.date.available2023-01-12T20:26:13Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: The purpose of the study was to investigate the relation between ARMS2 rs10490924 and HTRA1 rs11200638 polymorphisms, gender and exudative Age-Related Macular Degeneration (AMD) in Western Aegean population of Turkey. Materials and Methods: Diagnosis of exudative AMD was established on the basis of fundus examination, spectral domain optical coherence tomography and fl uorescein angiography. Genomic DNA samples were extracted from 75 patients with exudative AMD and 75 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotype frequencies of the rs10490924 and rs11200638 polymorphisms. Results: In the evaluations regardless of gender, thymine risk allele of the rs10490924 was slightly frequent in the exudative AMD group than in controls (p:0.028; OR: 1.291). Women with risk allel for rs10490924 had a higher risk for exudative AMD (p= 0.009, OR= 2.527) than men (p=0.504, OR= 1.233). The disease risk in those with TT genotype was higher in women (p:0.025, OR:5.14) than in men (p= 0.621, OR= 1.54). The risk allele (A) of rs11200638 was signifi cantly associated with the disease in women (p= 0.004, OR= 2.917). Additionally, the frequency of AA genotype was higher in women patients (p= 0.016, OR= 4.53) than in men (p= 0.666, OR= 0.88). Conclusions: To our knowledge, our study is the fi rst one showing that the relation between the rs11200638 and exudative AMD development is more in female gender. We suggest that the relation between rs11200638 polymorphism and this disease be investigated in larger populations. © 2021 Gazi Eye Foundation. All rights reserved.en_US
dc.identifier.doi10.37845/ret.vit.2021.30.31
dc.identifier.endpage186en_US
dc.identifier.issn1300-1256
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85110623494en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage182en_US
dc.identifier.trdizinid506057en_US
dc.identifier.urihttps://doi.org/10.37845/ret.vit.2021.30.31
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/506057
dc.identifier.urihttps://hdl.handle.net/11454/79938
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGazi Eye Foundationen_US
dc.relation.ispartofRetina-Vitreusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExudative Age-Related Macular Degenerationen_US
dc.subjectGenderen_US
dc.subjectPolymorphismen_US
dc.subjectRs10490924en_US
dc.subjectRs11200638en_US
dc.subjectgenomic DNAen_US
dc.subjectserine protease HTRA1en_US
dc.subjectthymineen_US
dc.subjectage related macular degenerationen_US
dc.subjectageden_US
dc.subjectarms2 geneen_US
dc.subjectArticleen_US
dc.subjectbest corrected visual acuityen_US
dc.subjectbiomicroscopyen_US
dc.subjectcontrolled studyen_US
dc.subjectDNA polymorphismen_US
dc.subjectDNA purificationen_US
dc.subjectexudative age related degenerationen_US
dc.subjectfemaleen_US
dc.subjectfluorescence angiographyen_US
dc.subjectgeneen_US
dc.subjectgene frequencyen_US
dc.subjectgene identificationen_US
dc.subjectgene locusen_US
dc.subjectgenetic associationen_US
dc.subjectgenetic risken_US
dc.subjectgenetic variabilityen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectophthalmoscopyen_US
dc.subjectpathogenesisen_US
dc.subjectpolymerase chain reaction restriction fragment length polymorphismen_US
dc.subjectpopulation researchen_US
dc.subjectsex differenceen_US
dc.subjectspectral domain optical coherence tomographyen_US
dc.subjectTurkey (republic)en_US
dc.titleAssociation of arms2 gene rs10490924 and htra1 gene rs11200638 polymorphisms with exudative age-related macular degeneration in western aegean population of turkeyen_US
dc.typeArticleen_US

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