Association of arms2 gene rs10490924 and htra1 gene rs11200638 polymorphisms with exudative age-related macular degeneration in western aegean population of turkey
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Eye Foundation
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The purpose of the study was to investigate the relation between ARMS2 rs10490924 and HTRA1 rs11200638 polymorphisms, gender and exudative Age-Related Macular Degeneration (AMD) in Western Aegean population of Turkey. Materials and Methods: Diagnosis of exudative AMD was established on the basis of fundus examination, spectral domain optical coherence tomography and fl uorescein angiography. Genomic DNA samples were extracted from 75 patients with exudative AMD and 75 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotype frequencies of the rs10490924 and rs11200638 polymorphisms. Results: In the evaluations regardless of gender, thymine risk allele of the rs10490924 was slightly frequent in the exudative AMD group than in controls (p:0.028; OR: 1.291). Women with risk allel for rs10490924 had a higher risk for exudative AMD (p= 0.009, OR= 2.527) than men (p=0.504, OR= 1.233). The disease risk in those with TT genotype was higher in women (p:0.025, OR:5.14) than in men (p= 0.621, OR= 1.54). The risk allele (A) of rs11200638 was signifi cantly associated with the disease in women (p= 0.004, OR= 2.917). Additionally, the frequency of AA genotype was higher in women patients (p= 0.016, OR= 4.53) than in men (p= 0.666, OR= 0.88). Conclusions: To our knowledge, our study is the fi rst one showing that the relation between the rs11200638 and exudative AMD development is more in female gender. We suggest that the relation between rs11200638 polymorphism and this disease be investigated in larger populations. © 2021 Gazi Eye Foundation. All rights reserved.
Açıklama
Anahtar Kelimeler
Exudative Age-Related Macular Degeneration, Gender, Polymorphism, Rs10490924, Rs11200638, genomic DNA, serine protease HTRA1, thymine, age related macular degeneration, aged, arms2 gene, Article, best corrected visual acuity, biomicroscopy, controlled study, DNA polymorphism, DNA purification, exudative age related degeneration, female, fluorescence angiography, gene, gene frequency, gene identification, gene locus, genetic association, genetic risk, genetic variability, genotype, human, major clinical study, male, ophthalmoscopy, pathogenesis, polymerase chain reaction restriction fragment length polymorphism, population research, sex difference, spectral domain optical coherence tomography, Turkey (republic)
Kaynak
Retina-Vitreus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
30
Sayı
2
