Antimicrobial activity evalution of newly synthesized N,N-disubstituted taurinamidobenzenesulfonamide derivatives

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dc.authorscopusid14007203900
dc.authorscopusid57221255128
dc.authorscopusid6505991614
dc.contributor.authorAkgül Ö.
dc.contributor.authorAteş A.
dc.contributor.authorErmertcan Ş.
dc.date.accessioned2023-01-12T20:24:03Z
dc.date.available2023-01-12T20:24:03Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractHerein we synthesized 6 new N,N-disubstituted taurinamidobenzenesulfonamide derivatives and characterized their structures by means of1H and13C NMR, HR-MS analysis. In addition, their in vitro antibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria, and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2 (methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcus aureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptible pathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom in compound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against all bacterial strains. As a result, these results provide us to investigate the relationship between structural changes and antibacterial/antifungal activity, which can be further used to develop more effective taurine derivatives. © 2021, Turkish Chemical Society. All rights reserved.en_US
dc.description.sponsorshipSBAG-117S516; Ege Üniversitesi: 16-ECZ-012; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAKen_US
dc.description.sponsorshipThe authors are grateful for financial support from The Scientific and Technological Research Council of Turkey [TUBITAK; Project number: SBAG-117S516] and Ege University Scientific Research Projects Coordination Unit [Project number: 16-ECZ-012].en_US
dc.identifier.doi10.18596/jotcsa.834579
dc.identifier.endpage328en_US
dc.identifier.issn2149-0120
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85103246968en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage321en_US
dc.identifier.trdizinid396489en_US
dc.identifier.urihttps://doi.org/10.18596/jotcsa.834579
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/396489
dc.identifier.urihttps://hdl.handle.net/11454/79818
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Chemical Societyen_US
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectMicrodilutionen_US
dc.subjectTaurinamidobenzenesulfonamideen_US
dc.subjectTaurineen_US
dc.titleAntimicrobial activity evalution of newly synthesized N,N-disubstituted taurinamidobenzenesulfonamide derivativesen_US
dc.typeArticleen_US

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