Antimicrobial activity evalution of newly synthesized N,N-disubstituted taurinamidobenzenesulfonamide derivatives

Küçük Resim Yok

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Turkish Chemical Society

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Herein we synthesized 6 new N,N-disubstituted taurinamidobenzenesulfonamide derivatives and characterized their structures by means of1H and13C NMR, HR-MS analysis. In addition, their in vitro antibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria, and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2 (methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcus aureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptible pathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom in compound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against all bacterial strains. As a result, these results provide us to investigate the relationship between structural changes and antibacterial/antifungal activity, which can be further used to develop more effective taurine derivatives. © 2021, Turkish Chemical Society. All rights reserved.

Açıklama

Anahtar Kelimeler

Antibacterial, Antifungal, Microdilution, Taurinamidobenzenesulfonamide, Taurine

Kaynak

Journal of the Turkish Chemical Society, Section A: Chemistry

WoS Q Değeri

Scopus Q Değeri

Q4

Cilt

8

Sayı

1

Künye