Antimicrobial activity evalution of newly synthesized N,N-disubstituted taurinamidobenzenesulfonamide derivatives
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Chemical Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Herein we synthesized 6 new N,N-disubstituted taurinamidobenzenesulfonamide derivatives and characterized their structures by means of1H and13C NMR, HR-MS analysis. In addition, their in vitro antibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria, and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2 (methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcus aureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptible pathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom in compound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against all bacterial strains. As a result, these results provide us to investigate the relationship between structural changes and antibacterial/antifungal activity, which can be further used to develop more effective taurine derivatives. © 2021, Turkish Chemical Society. All rights reserved.
Açıklama
Anahtar Kelimeler
Antibacterial, Antifungal, Microdilution, Taurinamidobenzenesulfonamide, Taurine
Kaynak
Journal of the Turkish Chemical Society, Section A: Chemistry
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
8
Sayı
1
