The effect of delayed gastric emptying and absorption on pharmacokinetic parameters of lithium

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dc.contributor.authorBellibaş S.E.
dc.contributor.authorTuglular I.
dc.contributor.authorKayali A.
dc.date.accessioned2019-10-27T00:33:22Z
dc.date.available2019-10-27T00:33:22Z
dc.date.issued1995
dc.departmentEge Üniversitesien_US
dc.description.abstractGastrointestinal motility is one of the most important factors that can influence drug absorption from the gastrointestinal tract. The aim of the present study was to investigate the effect of delayed gastric emptying and intestinal transit on pharmacokinetic parameters of lithium. Treatment animals were administered an anticholinergic agent (propantheline bromide, 4 mg/kg, p.o.) 10 min before lithium chloride (1.5 mM/kg, p.o.) administration, whereas the control group was administered the same dose of lithium p.o., alone. Plasma lithium levels were measured by flame spectrophotometry and calculated with a computer programme (SIPHAR). Differences detected in AUC, fractionated AUC values, C max and t max suggest that using a delayed absorption process, it is possible to prolong by 272% the plateau time of the drug in the therapeutic range and this approach might be an alternative way to prevent some undesirable effects due to peak plasma levels above the maximal therapeutic level. This approach might be more important as an alternative for suitable slow release formulations. © 1995 Springer-Verlag.en_US
dc.identifier.doi10.1007/BF03226367en_US
dc.identifier.endpage133en_US
dc.identifier.issn0378-7966
dc.identifier.issue2en_US
dc.identifier.pmid8582438en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1007/BF03226367
dc.identifier.urihttps://hdl.handle.net/11454/24037
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofEuropean Journal of Drug Metabolism and Pharmacokineticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectabsorptionen_US
dc.subjectGastric emptyingen_US
dc.subjectlithiumen_US
dc.subjectpharmacokineticsen_US
dc.subjectplateau timeen_US
dc.titleThe effect of delayed gastric emptying and absorption on pharmacokinetic parameters of lithiumen_US
dc.typeArticleen_US

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