The effect of delayed gastric emptying and absorption on pharmacokinetic parameters of lithium
Küçük Resim Yok
Tarih
1995
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Gastrointestinal motility is one of the most important factors that can influence drug absorption from the gastrointestinal tract. The aim of the present study was to investigate the effect of delayed gastric emptying and intestinal transit on pharmacokinetic parameters of lithium. Treatment animals were administered an anticholinergic agent (propantheline bromide, 4 mg/kg, p.o.) 10 min before lithium chloride (1.5 mM/kg, p.o.) administration, whereas the control group was administered the same dose of lithium p.o., alone. Plasma lithium levels were measured by flame spectrophotometry and calculated with a computer programme (SIPHAR). Differences detected in AUC, fractionated AUC values, C max and t max suggest that using a delayed absorption process, it is possible to prolong by 272% the plateau time of the drug in the therapeutic range and this approach might be an alternative way to prevent some undesirable effects due to peak plasma levels above the maximal therapeutic level. This approach might be more important as an alternative for suitable slow release formulations. © 1995 Springer-Verlag.
Açıklama
Anahtar Kelimeler
absorption, Gastric emptying, lithium, pharmacokinetics, plateau time
Kaynak
European Journal of Drug Metabolism and Pharmacokinetics
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
20
Sayı
2
