TAp73? is Upregulated in the Most Common Human Cancers

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dc.authorscopusid56711929200
dc.authorscopusid36637710700
dc.authorscopusid57188814764
dc.authorscopusid35964476500
dc.authorscopusid57221949355
dc.authorscopusid53664427700
dc.contributor.authorIscan E.
dc.contributor.authorKarakülah G.
dc.contributor.authorEkin U.
dc.contributor.authorOzturk M.
dc.contributor.authorUzuner H.
dc.contributor.authorSuner A.
dc.date.accessioned2023-01-12T20:26:07Z
dc.date.available2023-01-12T20:26:07Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe transcription factor p73 is a member of the p53 tumor suppressor gene family and one of the key regulators of apoptosis. TP73 gene encodes two protein isoforms classes with diverse functions, TAp73 and DNp73, and TAp73 expression in tumor tissues is altered. Unlike the TP53 gene, TP73 is not mutated in cancers. Here, we sought to explore the expression of p73 isoforms across eight major cancer types using the publicly available data deposited at the GDC data portal and the TSVdb database. Our results showed that TAp73? is overexpressed in breast invasive carcinoma, stomach adenocarcinoma, lung squamous cell carcinoma, colon adenocarcinoma, and esophageal carcinoma tumors, whereas the expression of DNp73 isoforms is downregulated in breast invasive carcinoma (DNp73?,?,?), Prostate Adenocarcinoma (DNp73?), Lung Adenocarcinoma (DNp73?), Lung Squamous Cell Carcinoma (DNp73?) tumors. In summary, this study revealed that TAp73? has higher expression than the DNp73 isoforms in several cancer types.en_US
dc.identifier.doi10.31857/S0026898422020082
dc.identifier.issn0026-8984
dc.identifier.issue2en_US
dc.identifier.pmid35403622en_US
dc.identifier.scopus2-s2.0-85127882463en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage320en_US
dc.identifier.urihttps://doi.org/10.31857/S0026898422020082
dc.identifier.urihttps://hdl.handle.net/11454/79892
dc.identifier.volume56en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoruen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofMolekuliarnaia biologiiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcanceren_US
dc.subjectp73en_US
dc.subjectTCGA splicing variants analysisen_US
dc.subjectDNA binding proteinen_US
dc.subjectisoproteinen_US
dc.subjectnuclear proteinen_US
dc.subjectprotein p53en_US
dc.subjecttumor suppressor proteinen_US
dc.subjectgene expression regulationen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectmetabolismen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectGene Expression Regulation, Neoplasticen_US
dc.subjectHumansen_US
dc.subjectNuclear Proteinsen_US
dc.subjectProtein Isoformsen_US
dc.subjectTumor Suppressor Protein p53en_US
dc.subjectTumor Suppressor Proteinsen_US
dc.titleTAp73? is Upregulated in the Most Common Human Cancersen_US
dc.typeArticleen_US

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