TAp73? is Upregulated in the Most Common Human Cancers
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NLM (Medline)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The transcription factor p73 is a member of the p53 tumor suppressor gene family and one of the key regulators of apoptosis. TP73 gene encodes two protein isoforms classes with diverse functions, TAp73 and DNp73, and TAp73 expression in tumor tissues is altered. Unlike the TP53 gene, TP73 is not mutated in cancers. Here, we sought to explore the expression of p73 isoforms across eight major cancer types using the publicly available data deposited at the GDC data portal and the TSVdb database. Our results showed that TAp73? is overexpressed in breast invasive carcinoma, stomach adenocarcinoma, lung squamous cell carcinoma, colon adenocarcinoma, and esophageal carcinoma tumors, whereas the expression of DNp73 isoforms is downregulated in breast invasive carcinoma (DNp73?,?,?), Prostate Adenocarcinoma (DNp73?), Lung Adenocarcinoma (DNp73?), Lung Squamous Cell Carcinoma (DNp73?) tumors. In summary, this study revealed that TAp73? has higher expression than the DNp73 isoforms in several cancer types.
Açıklama
Anahtar Kelimeler
cancer, p73, TCGA splicing variants analysis, DNA binding protein, isoprotein, nuclear protein, protein p53, tumor suppressor protein, gene expression regulation, genetics, human, metabolism, squamous cell carcinoma, Carcinoma, Squamous Cell, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Humans, Nuclear Proteins, Protein Isoforms, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Kaynak
Molekuliarnaia biologiia
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
56
Sayı
2
