Effect of Tamsulosin on Corneal Biomechanical Features
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AAmmaaçç
Objective: Tamsulosin (Flomax®) usage was reported to increase central corneal thickness (CCT). As CCT and ocular biomechanical parameters are closely related, this study was conducted to investigate the possible effects of tamsulosin on biomechanical parameters of cornea as measured with Reichert Ocular Response Analyser (ORA) in patients with benign prostate hyperplasia. Material and Methods: Besides full eye examination (best corrected visual acuity, intraocular pressure (IOP) measured with Goldmann applanation tonometry, CCT) ORA (corneal hysteresis, corneal resistance factor, corneal compensated IOP, Goldmann correlated IOP) measurements of 30 eyes of 15 male patients before and one month after tamsulosin therapy were performed. For comparisons paired t-test was used. Results: Mean age in the study group was 61.50±6.10 (range 47-69) years. Pre-tamsulosin CCT was lower than post-tamsulosin values (pre-: 549.18±28.84 micrometers, post-: 556.77±24.86 micrometers; p=0.002). Although statistically insignificant corneal resistance factor after tamsulosin use was lower (pre-: 10.73±1.05 mmHg, post-: 9.45±1.51 mmHg; p=0.071). Measurements before and after tamsulosin treatment was not statistically different for any of the other parameters. Conclusion: Tamsulosin seems not only to cause an increment on CCT, but also effect corneal resistance factor. the long term effects of tamsulosin on corneal biomechanical properties should further be investigated with larger group of patients.
Objective: Tamsulosin (Flomax®) usage was reported to increase central corneal thickness (CCT). As CCT and ocular biomechanical parameters are closely related, this study was conducted to investigate the possible effects of tamsulosin on biomechanical parameters of cornea as measured with Reichert Ocular Response Analyser (ORA) in patients with benign prostate hyperplasia. Material and Methods: Besides full eye examination (best corrected visual acuity, intraocular pressure (IOP) measured with Goldmann applanation tonometry, CCT) ORA (corneal hysteresis, corneal resistance factor, corneal compensated IOP, Goldmann correlated IOP) measurements of 30 eyes of 15 male patients before and one month after tamsulosin therapy were performed. For comparisons paired t-test was used. Results: Mean age in the study group was 61.50±6.10 (range 47-69) years. Pre-tamsulosin CCT was lower than post-tamsulosin values (pre-: 549.18±28.84 micrometers, post-: 556.77±24.86 micrometers; p=0.002). Although statistically insignificant corneal resistance factor after tamsulosin use was lower (pre-: 10.73±1.05 mmHg, post-: 9.45±1.51 mmHg; p=0.071). Measurements before and after tamsulosin treatment was not statistically different for any of the other parameters. Conclusion: Tamsulosin seems not only to cause an increment on CCT, but also effect corneal resistance factor. the long term effects of tamsulosin on corneal biomechanical properties should further be investigated with larger group of patients.
Açıklama
Anahtar Kelimeler
Göz Hastalıkları
Kaynak
Türkiye Klinikleri Oftalmoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
1
