Synthesis and anticonvulsant activity of some alkanamide derivatives

Basit Öğe Kaydı
dc.contributor.authorTarikogullari A.H.
dc.contributor.authorKilic F.S.
dc.contributor.authorErol K.
dc.contributor.authorPabuccuoglu V.
dc.date.accessioned2019-10-26T22:28:42Z
dc.date.available2019-10-26T22:28:42Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractA group of N -phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at ? position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(2,6-dimethylphenyl)acetamide. © ECV · Editio Cantor Verlag.en_US
dc.identifier.endpage598en_US
dc.identifier.issn0004-4172
dc.identifier.issue10en_US
dc.identifier.pmid21125808en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://hdl.handle.net/11454/19653
dc.identifier.volume60en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkanamideen_US
dc.subjectAnilideen_US
dc.subjectAnticonvulsant drugsen_US
dc.subjectImidazoleen_US
dc.subjectPyrazoleen_US
dc.subjectTriazoleen_US
dc.titleSynthesis and anticonvulsant activity of some alkanamide derivativesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu