Synthesis and anticonvulsant activity of some alkanamide derivatives
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A group of N -phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at ? position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(2,6-dimethylphenyl)acetamide. © ECV · Editio Cantor Verlag.
Açıklama
Anahtar Kelimeler
Alkanamide, Anilide, Anticonvulsant drugs, Imidazole, Pyrazole, Triazole
Kaynak
Arzneimittel-Forschung/Drug Research
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
60
Sayı
10
