Atypia and Differential Diagnosis in Cellular Blue Nevi: Clinicopathological Study of 21 Cases

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dc.contributor.authorYaman, Banu
dc.contributor.authorKandiloglu, Gulsen
dc.contributor.authorSarsik Kumbaraci, Banu
dc.contributor.authorAkalin, Taner
dc.date.accessioned2019-10-27T23:00:34Z
dc.date.available2019-10-27T23:00:34Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Cellular blue nevus differs from the classic blue nevus with characteristics such as large size, cellularity, intense pigmentation, and growing pattern with subcutaneous infiltration. It is a dermal melanocytic tumor that can be confused with melanoma due to the atypia it may contain. Material and Method: Hematoxylin-eosin and MIB-1 stained slides of 21 cases diagnosed between 2000-2014 were re-evaluated. In order to attract attention to this rare lesion, 21 cases are presented with the clinical and above-mentioned histopathological findings. Results: Thirteen (61.9%) cases were females and eight (38.1%) were male. The mean age was 25.4 (2-73). The most frequent localization was the sacral and gluteal region (11 cases). The mean diameter was 14.4 mm (4-60 mm). From the parameters defined to assess the atypia, ulceration was identified in four cases. Prominent cellularity and subcutaneous infiltration were seen in three and 16 cases, respectively. Mitosis was seen in six tumors. Immunohistochemically, MIB-1 was present in two cases as 3% and 2% respectively, while in others it was 1% or less. Although there is no precise definition for the "atypical cellular blue nevus", five patients were assessed as atypical cellular blue nevus (a case with infiltrative development of six cm tumor diameter, two cases with two mitosis and a MIB-1 index 3% and 2%, a case with one mitosis and confluent development and a case with one mitosis in addition to focal necrosis areas). No lymph node and/or distant metastasis was observed during follow-up. Conclusion: We think it is more important to rule out the possibility of conventional melanoma in cellular blue nevus with exaggerated morphological findings alongside low proliferative activity rather than to determine the atypia.en_US
dc.identifier.doi10.5146/tjpath.2014.01296
dc.identifier.endpage94en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid25690862en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2014.01296
dc.identifier.urihttps://hdl.handle.net/11454/52025
dc.identifier.volume31en_US
dc.identifier.wosWOS:000367954000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofTurkish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCellular blue nevusen_US
dc.subjectDifferential diagnosisen_US
dc.subjectMIB-1 proteinen_US
dc.titleAtypia and Differential Diagnosis in Cellular Blue Nevi: Clinicopathological Study of 21 Casesen_US
dc.typeArticleen_US

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