Association between IL4 (-590), ACE (I)/(D), CCR5 (?32), CTLA4 (+49) and ILl-RN (VNTR in intron 2) gene polymorphisms and vitiligo

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dc.contributor.authorSacide Pehlivan
dc.contributor.authorÖzkınay F.
dc.contributor.authorAlper S.
dc.contributor.authorOnay H.
dc.contributor.authorYuksel E.
dc.contributor.authorPehlivan M.
dc.contributor.authorÖzkınay, Cihangir
dc.date.accessioned2019-10-26T23:01:08Z
dc.date.available2019-10-26T23:01:08Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractVitiligo is a common skin disorder characterized by patterned depig-mentation, because of a decrease of melanin pigment resulting from apparent melanocyte loss. The aim of this study was to investigate interleukin 4 (IL4), Angiotensin Converting Enzyme (ACE), C-C Che-mocine Receptor 5 (CCR5), Cytotoxic T Lymphocyte-associated Anti-gen Receptor 4 (CTLA4) and Interleukin 1 Receptor Antagonist (ILl-RN) gene polymorphisms in 48 Turkish vitiligo patients and 50 healthy controls. Polymorphisms for the genes ACE insertion(I)/dele- tion(D), CCR5 (A32), ILl-RN (VNTR in intron 2) were detected by PCR methods. IL4 (-590) and CTLA4 (+49) gene polymorphisms were typed using PCR-RFLP methods. No significant differences in either the genotype distribution or allele frequencies of IL4, CCR5 and ACE gene polymorphisms were observed. GG genotype and G allele in CTLA4 genes were found to be significantly higher in vitiligo patients compared to the controls. (0.002, 0.000). CTLA4 (AA) and ILl-RN (1/5) genotypes and 5 allele frequency in the ILl-RN gene were found to be significantly lower in vitiligo patients compared to healthy controls (p: 0.014, 0.015, 0.016, respectively). As a conclu-sion, CTLA4 and ILl-RN genes might play roles in the genetic etiology of vitiligo.en_US
dc.identifier.endpage128en_US
dc.identifier.issn1167-1122
dc.identifier.issue2en_US
dc.identifier.pmid19129082en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/11454/20575
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectACEen_US
dc.subjectCCR5en_US
dc.subjectCTLA4en_US
dc.subjectIL4en_US
dc.subjectILl-RNen_US
dc.subjectPolymorphismsen_US
dc.subjectVitiligoen_US
dc.titleAssociation between IL4 (-590), ACE (I)/(D), CCR5 (?32), CTLA4 (+49) and ILl-RN (VNTR in intron 2) gene polymorphisms and vitiligoen_US
dc.typeArticleen_US

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