Association between IL4 (-590), ACE (I)/(D), CCR5 (?32), CTLA4 (+49) and ILl-RN (VNTR in intron 2) gene polymorphisms and vitiligo
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Vitiligo is a common skin disorder characterized by patterned depig-mentation, because of a decrease of melanin pigment resulting from apparent melanocyte loss. The aim of this study was to investigate interleukin 4 (IL4), Angiotensin Converting Enzyme (ACE), C-C Che-mocine Receptor 5 (CCR5), Cytotoxic T Lymphocyte-associated Anti-gen Receptor 4 (CTLA4) and Interleukin 1 Receptor Antagonist (ILl-RN) gene polymorphisms in 48 Turkish vitiligo patients and 50 healthy controls. Polymorphisms for the genes ACE insertion(I)/dele- tion(D), CCR5 (A32), ILl-RN (VNTR in intron 2) were detected by PCR methods. IL4 (-590) and CTLA4 (+49) gene polymorphisms were typed using PCR-RFLP methods. No significant differences in either the genotype distribution or allele frequencies of IL4, CCR5 and ACE gene polymorphisms were observed. GG genotype and G allele in CTLA4 genes were found to be significantly higher in vitiligo patients compared to the controls. (0.002, 0.000). CTLA4 (AA) and ILl-RN (1/5) genotypes and 5 allele frequency in the ILl-RN gene were found to be significantly lower in vitiligo patients compared to healthy controls (p: 0.014, 0.015, 0.016, respectively). As a conclu-sion, CTLA4 and ILl-RN genes might play roles in the genetic etiology of vitiligo.
Açıklama
Anahtar Kelimeler
ACE, CCR5, CTLA4, IL4, ILl-RN, Polymorphisms, Vitiligo
Kaynak
European Journal of Dermatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
19
Sayı
2
