Synthesis and biological evaluation of bisphosphonate compound labeled with 99m Tc(CO) 3 +

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dc.contributor.authorŞenocak K.
dc.contributor.authorTeksöz S.
dc.contributor.authorI?hedef C¸.
dc.contributor.authorU?ar E.
dc.date.accessioned2019-10-27T08:21:05Z
dc.date.available2019-10-27T08:21:05Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, radiolabeling of a bisphosphonate, alendronate (Alendronate sodium), was performed with the help of a bifunctional chelating agent. For that purpose, DTPA-NHS (Diethylenetriaminepentaacetic acid dianhydride-N-hydroxysuccinimide) was synthesized with an esterification between DTPA and NHS. Combining the DTPA-NHS ester with alendronate yields the DTPA-Alendronate compound. The structure of synthesized compound was analyzed by 1 H/ 13 C/ 31 P-NMR and HPLC. After then, the labeling with [ 99m Tc(CO) 3 ] + core of synthesized compound was provided. Performing quality controls of newly synthesized [ 99m Tc(CO) 3 -DTPA-Alendronate] complex with thin layer radiochromatography (TLRC) and high-performance liquid radiochromatography (HPLRC), the labeling yield was found as 99%. It was observed that the compound conserves its stability for 24 h in serum media. Biodistribution of the radiolabeled complex was performed on Wistar Albino rats to determine radiopharmaceutical potential of the [ 99m Tc(CO) 3 -DTPA-Alendronate] complex. It is thought that the data gained from this study will contribute to the development of complexes with bisphosphonate. © 2014 John Wiley & Sons A/S.en_US
dc.identifier.doi10.1111/cbdd.12401en_US
dc.identifier.endpage376en_US
dc.identifier.issn1747-0277
dc.identifier.issue3en_US
dc.identifier.pmid25092179en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.1111/cbdd.12401
dc.identifier.urihttps://hdl.handle.net/11454/25914
dc.identifier.volume85en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofChemical Biology and Drug Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99m Tc(CO) 3 + coreen_US
dc.subjectBiodistributionen_US
dc.subjectBisphosphonateen_US
dc.subjectDTPAen_US
dc.titleSynthesis and biological evaluation of bisphosphonate compound labeled with 99m Tc(CO) 3 +en_US
dc.typeArticleen_US

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