Synthesis and biological evaluation of bisphosphonate compound labeled with 99m Tc(CO) 3 +
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Publishing Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, radiolabeling of a bisphosphonate, alendronate (Alendronate sodium), was performed with the help of a bifunctional chelating agent. For that purpose, DTPA-NHS (Diethylenetriaminepentaacetic acid dianhydride-N-hydroxysuccinimide) was synthesized with an esterification between DTPA and NHS. Combining the DTPA-NHS ester with alendronate yields the DTPA-Alendronate compound. The structure of synthesized compound was analyzed by 1 H/ 13 C/ 31 P-NMR and HPLC. After then, the labeling with [ 99m Tc(CO) 3 ] + core of synthesized compound was provided. Performing quality controls of newly synthesized [ 99m Tc(CO) 3 -DTPA-Alendronate] complex with thin layer radiochromatography (TLRC) and high-performance liquid radiochromatography (HPLRC), the labeling yield was found as 99%. It was observed that the compound conserves its stability for 24 h in serum media. Biodistribution of the radiolabeled complex was performed on Wistar Albino rats to determine radiopharmaceutical potential of the [ 99m Tc(CO) 3 -DTPA-Alendronate] complex. It is thought that the data gained from this study will contribute to the development of complexes with bisphosphonate. © 2014 John Wiley & Sons A/S.
Açıklama
Anahtar Kelimeler
99m Tc(CO) 3 + core, Biodistribution, Bisphosphonate, DTPA
Kaynak
Chemical Biology and Drug Design
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
85
Sayı
3
