Is it possible to diagnose infectious oesophagitis without seeing the causative organism? A histopathological study

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dc.contributor.authorDemir, Derya
dc.contributor.authorDoganavsargil, Basak
dc.contributor.authorSarsik, Banu
dc.contributor.authorSezak, Murat
dc.contributor.authorTuncyurek, Muge
dc.date.accessioned2019-10-27T22:12:52Z
dc.date.available2019-10-27T22:12:52Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: We investigated the utility of using histological changes to diagnose infectious oesophagitis when causative organisms cannot be seen. Materials and Methods: Sixty-seven endoscopic biopsy specimens (51 Candida, 9 herpes simplex virus, 4 tuberculosis, and 3 cytomegalovirus oesophagitis) collected from 2000-2010 that matched the investigative criteria were included in the study. Cases were re-evaluated for histological changes observed in oesophagitis, and the findings were statistically compared using nonparametric tests. Results: Thirty-nine cases occurred in male patients, and 28 occurred in female patients; the mean age of the patients was 51 +/- 20.1 years (range, 5-94 years). All cases showed lymphocytic and neutrophilic infiltration; while 27 (40.3%) showed eosinophilic infiltration. The density of lymphocytes and eosinophils were 8.43 +/- 6 and 1.07 +/- 1.62 per high power field, respectively, and these rates were higher in tuberculosis oesophagitis cases. Lamina propria infiltration was present in herpes simplex virus and Candida oesophagitis. Dense neutrophilic infiltration (>50/high power field) was noted in herpes simplex virus oesophagitis. Candida colonization was observed in 82% of cases with eosinophilic infiltration, and 80% of cases with erosion. Ulceration was present in all tuberculosis oesophagitis cases (p<0.001). Basal cell hyperplasia, papillary elongation, and dilated intercellular spaces were seen in all cases except for 2 Candida oesophagitis cases. Lamina propria fibrosis was especially noted in cytomegalovirus oesophagitis cases. Conclusion: It is not possible to distinguish infectious oesophagitis from other subtypes, especially reflux oesophagitis, if the causative organism is not detected. Clinicopathological correlation and control with repeat targeted biopsies are essential for diagnosis.en_US
dc.identifier.doi10.5152/tjg.2014.4967
dc.identifier.endpage487en_US
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.pmid25417607en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2014.4967
dc.identifier.urihttps://hdl.handle.net/11454/49621
dc.identifier.volume25en_US
dc.identifier.wosWOS:000345023700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfectiousen_US
dc.subjectoesophagitisen_US
dc.subjectcytomegalovirusen_US
dc.subjectherpes simplex virusen_US
dc.subjectcandidaen_US
dc.titleIs it possible to diagnose infectious oesophagitis without seeing the causative organism? A histopathological studyen_US
dc.typeArticleen_US

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