The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients

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dc.contributor.authorBastu, Ercan
dc.contributor.authorGokulu, Sevki Goksun
dc.contributor.authorDural, Ozlem
dc.contributor.authorYasa, Cenk
dc.contributor.authorBulgurcuoglu, Sibel
dc.contributor.authorBalci, Burcin Karamustafaoglu
dc.contributor.authorCelik, Cem
dc.contributor.authorBuyru, Faruk
dc.date.accessioned2019-10-27T19:53:55Z
dc.date.available2019-10-27T19:53:55Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the relationship of cathepsin B, relaxin and anti-Mullerian hormone (AMH) in follicular fluid (FF) with pregnancy rates in infertility patients. Study design: Seventy-nine infertile couples who underwent ICSI were included in the study. The FF levels of cathepsin B, relaxin and AMH were measured using ELISA kits. Results: The FF cathepsin B levels were statistically higher in pregnant patients compared with nonpregnant patients (0.20 +/- 0.13 versus 0.13 +/- 0.03; P < 0.001). There were statistically significant differences in the total number of oocytes (10.00 +/- 6.85 versus 5.96 +/- 3.94); the mean number of M2 oocytes (8.65 +/- 5.63 versus 4.58 +/- 3.36) between the pregnant and non-pregnant patients (P < 0.05). There were no significant correlations between pregnancy rates and relaxin and AMH (P > 0.05). The area under the curve of cathepsin B for prediction of pregnancy was 0.662 (p = 0.024, 95% Confidence Interval 0.528-0.797). Conclusions: This study demonstrated that increased level of cathepsin B in FF significantly correlates with a better chance of clinical pregnancy. Further studies are needed to clarify the role of cathepsin B in the reproductive process of humans. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2015.02.009en_US
dc.identifier.endpage34en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid25739053en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2015.02.009
dc.identifier.urihttps://hdl.handle.net/11454/40382
dc.identifier.volume187en_US
dc.identifier.wosWOS:000353091800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCathepsin Ben_US
dc.subjectRelaxinen_US
dc.subjectAMHen_US
dc.subjectFollicular fluiden_US
dc.subjectInfertilityen_US
dc.titleThe association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patientsen_US
dc.typeArticleen_US

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