The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study was to investigate the relationship of cathepsin B, relaxin and anti-Mullerian hormone (AMH) in follicular fluid (FF) with pregnancy rates in infertility patients. Study design: Seventy-nine infertile couples who underwent ICSI were included in the study. The FF levels of cathepsin B, relaxin and AMH were measured using ELISA kits. Results: The FF cathepsin B levels were statistically higher in pregnant patients compared with nonpregnant patients (0.20 +/- 0.13 versus 0.13 +/- 0.03; P < 0.001). There were statistically significant differences in the total number of oocytes (10.00 +/- 6.85 versus 5.96 +/- 3.94); the mean number of M2 oocytes (8.65 +/- 5.63 versus 4.58 +/- 3.36) between the pregnant and non-pregnant patients (P < 0.05). There were no significant correlations between pregnancy rates and relaxin and AMH (P > 0.05). The area under the curve of cathepsin B for prediction of pregnancy was 0.662 (p = 0.024, 95% Confidence Interval 0.528-0.797). Conclusions: This study demonstrated that increased level of cathepsin B in FF significantly correlates with a better chance of clinical pregnancy. Further studies are needed to clarify the role of cathepsin B in the reproductive process of humans. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Cathepsin B, Relaxin, AMH, Follicular fluid, Infertility
Kaynak
European Journal of Obstetrics & Gynecology and Reproductive Biology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
187
