Can impairments of thyroid function test affect prognosis in patients with respiratory failure?

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dc.contributor.authorBacakoglu F.
dc.contributor.authorBaşoglu Ö.K.
dc.contributor.authorGürgün A.
dc.contributor.authorBayraktar F.
dc.contributor.authorKiran B.
dc.contributor.authorÖzhan M.H.
dc.date.accessioned2019-10-26T23:58:47Z
dc.date.available2019-10-26T23:58:47Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThyroid function test (TFT) impairments can be detected in extrathyroidal dysfunction, primarily in chronic obstructive pulmonary disease (COPD) with acute respiratory failure (RF). The aims of this study were to: (i) evaluate TFT impairments in patients with RF, (ii) compare TFT results to a control group without RF and (iii) assess the effects of thyroid dysfunction on clinical outcome and prognosis of RF. The TFT parameters were assessed in 65 patients (65.0 ± 10.0 years, 49 males) with RF and compared to 18 patients (64.4 ± 9.8 years, 13 males) with lung disease and no RF (p> 0.05). Arterial blood I gas analysis, free T3 (FT3), free T4 (FT4) and TSH levels were all measured. The impairments of TFT were demonstrated in \ 34 (52.3%) patients with RF and 8 (44.4%) patients without RF (p> 0.05). The most common finding was a decrease in at least one of the TFT parameters in both groups (43.1% vs. 44.4%, respectively), in RF group, there was no significant association between TFT results and gender, age, diagnosis and co-morbid disease. However, need for invasive mechanical ventilation was higher both in patients with low FT3 and low FT4 when compared to those with normal TFT results (p= 0.001 and p= 0.003, respectively). In-hospital mortality rate was also higher both in the patients with low FT3 and low FT4 than the others (p= 0.006 and p= 0.07, respectively). We conclude that TFT impairments are not observed more frequently in patients with RF when compared to the patients without RF. However, low FT3 and FT4 levels increase the rates of invasive mechanical ventilation and mortality.en_US
dc.identifier.endpage335en_US
dc.identifier.issn0494-1373
dc.identifier.issue4en_US
dc.identifier.pmid18224499en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://hdl.handle.net/11454/21282
dc.identifier.volume55en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTuberkuloz ve Toraksen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOPDen_US
dc.subjectMortalityen_US
dc.subjectRespiratory failureen_US
dc.subjectThyroid dysfunctionen_US
dc.subjectThyroid function testen_US
dc.titleCan impairments of thyroid function test affect prognosis in patients with respiratory failure?en_US
dc.typeArticleen_US

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