Fine needle aspiration cytology of mammary carcinoma with choriocarcinomatous features - A report of 2 cases

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dc.contributor.authorAkbulut, Metin
dc.contributor.authorZekioglu, Osinan
dc.contributor.authorOzdemir, Necmettin
dc.contributor.authorKapkac, Murat
dc.date.accessioned2019-10-27T19:55:58Z
dc.date.available2019-10-27T19:55:58Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description18th National Pathology Symposium -- MAY 07-11, 2006 -- Izmir, TURKEYen_US
dc.description.abstractBackground Neoplasms of the breast containing multinucleated giant cells (MGCs) include both benign and malignant entities, such as benign soft tissue giant cell tumors, atypical fibrous histiocytoma, sarcomas, metaplastic carcinomas and the uncommon carcinomas containing osteoclast-like giant cells (OGC). Breast carcinoma with choriocarcinomatous features (BCCF) is a distinct variant of breast cancer. Cases We report the cytologic features, pathologic findings and immunohistochemical profile in 2 cases of this unusual variant of breast carcinoma. Two women aged 53 and 50 years women presented with a history of left and right breast lump hut no local lymphadenopathy, respectively. Fine needle aspiration cytology (FNAC) of both cases revealed abundant MGC with highly pleomorphic tumor cells in the hemorrhagic necrotic background. Both of the cases were histopathologically diagnosed as BCCF. Conclusion Choriocarcinomatous differentiation with multinucleated syncytiotrophoblast-like giant cells is extremely bare in breast tumors. Although rare, FNAC of breast cancer with pleomorphic MGC requires carefull search for differential diagnosis, breast carcinoma with giant cell features (choriocarcinomatous features, OGC features) must be differentiated from metastatic tumors and other breast lesions containing giant cells.en_US
dc.identifier.doi10.1159/000325443en_US
dc.identifier.endpage104en_US
dc.identifier.issn0001-5547
dc.identifier.issn1938-2650
dc.identifier.issue1en_US
dc.identifier.pmid18323284en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1159/000325443
dc.identifier.urihttps://hdl.handle.net/11454/40756
dc.identifier.volume52en_US
dc.identifier.wosWOS:000252723600016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Cytologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarcinomaen_US
dc.subjectbreasten_US
dc.subjectchoriocarcinomatous featuresen_US
dc.subjectgiant cellsen_US
dc.subjectmultinucleateden_US
dc.titleFine needle aspiration cytology of mammary carcinoma with choriocarcinomatous features - A report of 2 casesen_US
dc.typeArticleen_US

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