Fine needle aspiration cytology of mammary carcinoma with choriocarcinomatous features - A report of 2 cases
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Neoplasms of the breast containing multinucleated giant cells (MGCs) include both benign and malignant entities, such as benign soft tissue giant cell tumors, atypical fibrous histiocytoma, sarcomas, metaplastic carcinomas and the uncommon carcinomas containing osteoclast-like giant cells (OGC). Breast carcinoma with choriocarcinomatous features (BCCF) is a distinct variant of breast cancer. Cases We report the cytologic features, pathologic findings and immunohistochemical profile in 2 cases of this unusual variant of breast carcinoma. Two women aged 53 and 50 years women presented with a history of left and right breast lump hut no local lymphadenopathy, respectively. Fine needle aspiration cytology (FNAC) of both cases revealed abundant MGC with highly pleomorphic tumor cells in the hemorrhagic necrotic background. Both of the cases were histopathologically diagnosed as BCCF. Conclusion Choriocarcinomatous differentiation with multinucleated syncytiotrophoblast-like giant cells is extremely bare in breast tumors. Although rare, FNAC of breast cancer with pleomorphic MGC requires carefull search for differential diagnosis, breast carcinoma with giant cell features (choriocarcinomatous features, OGC features) must be differentiated from metastatic tumors and other breast lesions containing giant cells.
Açıklama
18th National Pathology Symposium -- MAY 07-11, 2006 -- Izmir, TURKEY
Anahtar Kelimeler
carcinoma, breast, choriocarcinomatous features, giant cells, multinucleated
Kaynak
Acta Cytologica
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
52
Sayı
1
