Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016

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dc.contributor.authorAksoy, Semiha Cetinel
dc.contributor.authorUzel, Atac
dc.contributor.authorBedir, Erdal
dc.date.accessioned2019-10-27T22:58:23Z
dc.date.available2019-10-27T22:58:23Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractRocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional (H-1 and C-13) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S361]; Scientific Research Foundation of Ege UniversityEge University [10-FEN-012]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 109S361) and the Scientific Research Foundation of Ege University (10-FEN-012).en_US
dc.identifier.doi10.1038/ja.2015.72en_US
dc.identifier.endpage56en_US
dc.identifier.issn0021-8820
dc.identifier.issue1en_US
dc.identifier.pmid26126744en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1038/ja.2015.72
dc.identifier.urihttps://hdl.handle.net/11454/51532
dc.identifier.volume69en_US
dc.identifier.wosWOS:000370676800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Antibiotics Research Assocen_US
dc.relation.ispartofJournal of Antibioticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016en_US
dc.typeArticleen_US

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