Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase

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dc.contributor.authorTopcu, Zeki
dc.contributor.authorOzturk, Bintug
dc.contributor.authorKucukoglu, Ozlem
dc.contributor.authorKilinc, Emrah
dc.date.accessioned2019-10-27T19:58:21Z
dc.date.available2019-10-27T19:58:21Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractDNA topoisomerases are important targets for cancer chemotherapy. We investigated the effects of a methanolic extract of Helichrysum pamphylicum on mammalian DNA topoisomerase I via in vitro plasmid supercoil relaxation assays. The extracts manifested a considerable inhibition of the enzyme's activity in a dose-dependent manner. We also performed a HPLC analysis to identify the flavonoid content of the H. pamphylicum extract and tested the identified flavonoids; luteolin, luteolin-4-glucoside, naringenin, helichrysinA and isoquercitrin, on DNA topoisomerase I activity. The measurement of the total antioxidant capacity of the flavonoid standards suggested that the topoisomerase inhibition might be correlated with the antioxidant capacity of the plant.en_US
dc.identifier.endpage74en_US
dc.identifier.issn0939-5075
dc.identifier.issue01.Feben_US
dc.identifier.pmid18386491en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://hdl.handle.net/11454/41063
dc.identifier.volume63en_US
dc.identifier.wosWOS:000254633400013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerlag Z Naturforschen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelichrysurn pamphylicumen_US
dc.subjectDNA topoisomeraseen_US
dc.titleFlavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomeraseen_US
dc.typeArticleen_US

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