Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verlag Z Naturforsch
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
DNA topoisomerases are important targets for cancer chemotherapy. We investigated the effects of a methanolic extract of Helichrysum pamphylicum on mammalian DNA topoisomerase I via in vitro plasmid supercoil relaxation assays. The extracts manifested a considerable inhibition of the enzyme's activity in a dose-dependent manner. We also performed a HPLC analysis to identify the flavonoid content of the H. pamphylicum extract and tested the identified flavonoids; luteolin, luteolin-4-glucoside, naringenin, helichrysinA and isoquercitrin, on DNA topoisomerase I activity. The measurement of the total antioxidant capacity of the flavonoid standards suggested that the topoisomerase inhibition might be correlated with the antioxidant capacity of the plant.
Açıklama
Anahtar Kelimeler
Helichrysurn pamphylicum, DNA topoisomerase
Kaynak
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
63
Sayı
01.Feb
