How Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study

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dc.authoridBAŞARAN, ÖZCAN/0000-0002-6384-6455
dc.authorscopusid36472957600
dc.authorscopusid24073063700
dc.authorscopusid56433330200
dc.authorscopusid57191478217
dc.authorscopusid57191477943
dc.authorscopusid58065587700
dc.authorscopusid58093214700
dc.authorwosidBAŞARAN, ÖZCAN/H-4217-2019
dc.contributor.authorBasaran, Ozcan
dc.contributor.authorDogan, Volkan
dc.contributor.authorMert, Kadir Ugur
dc.contributor.authorOzlek, Bulent
dc.contributor.authorOzlek, Eda
dc.contributor.authorCelik, Oguzhan
dc.contributor.authorCil, Cem
dc.date.accessioned2024-08-25T18:48:39Z
dc.date.available2024-08-25T18:48:39Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The recent 2019 European Society of Cardiology/European Atherosclerosis Society practice guidelines introduced a new risk categorization for patients with dia-betes. We aimed to compare the implications of the 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society guidelines with regard to the lipid-lowering treatment use, low-density lipoprotein cholesterol goal attainment rates, and the esti-mated proportion of patients who would be at goal in an ideal setting. Methods: Patients with diabetes were classified into 4 risk categories according to 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidemia guidelines from the database of EPHESUS (cross-sectional, observational, countrywide registry of cardiology outpatient clinics) study. The use of lipid-lowering treatment and low-density lipoprotein cholesterol goal attainment rates were then compared accord-ing to previous and new guidelines.Results: This analysis included a total of 873 diabetic adults. Half of the study popula-tion (53.8%) were on lipid-lowering treatment and almost one-fifth (19.1%) were on high -intensity statins. While low-density lipoprotein cholesterol goal was achieved in 19.5% and 7.5% of patients, 87.4% and 69.6% would be on target if their lipid-lowering treatment was intensified according to 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society lipid guidelines, respectively. The new target <55 mg/dL could only be achieved in 2.2% and 8.1% of very high-risk primary prevention and secondary pre-vention patients, respectively.Conclusion: The control of dyslipidemia was extremely poor among patients with diabe-tes. The use of lipid-lowering treatment was not at the desired level, and high-intensity lipid-lowering treatment use was even lower. Our simulation model showed that the high -dose statin plus ezetimibe therapy would improve goal attainment; however, it would not be possible to get goals with this treatment in more than one-third of the patients.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2022.2012
dc.identifier.endpage+en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid36747449en_US
dc.identifier.scopus2-s2.0-85147461050en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage78en_US
dc.identifier.trdizinid1168597en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2022.2012
dc.identifier.urihttps://hdl.handle.net/11454/102356
dc.identifier.volume27en_US
dc.identifier.wosWOS:000956673700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectDiabetes mellitusen_US
dc.subjectdyslipidemiaen_US
dc.subjectatherosclerosisen_US
dc.subjectlipid guidelinesen_US
dc.subjectlow-density lipoprotein cholesterolen_US
dc.subjectcardiovascular risken_US
dc.subjectNon-Hdl-Cholesterolen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectGuidelinesen_US
dc.subjectDyslipidemiaen_US
dc.subjectManagementen_US
dc.subjectCommunityen_US
dc.titleHow Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Studyen_US
dc.typeArticleen_US

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