Synthesis of thiourea and sugar derivatives of some chiral aromatic compounds and investigations of their biological activities
| dc.contributor.advisor | Astley, Demet | |
| dc.contributor.author | Yüksekdanacı, Seda | |
| dc.date.accessioned | 2020-10-30T06:37:56Z | |
| dc.date.available | 2020-10-30T06:37:56Z | |
| dc.date.issued | 2017 | en_US |
| dc.date.submitted | 2017 | |
| dc.department | Fen Bilimleri Enstitüsü | en_US |
| dc.description.abstract | In this study, L-isoleucine, D-phenylglycine, D-phenylalanine and L-valine were used as starting amino acids. First of all, N-Boc-amino acids derivatives were synthesized. Amide derivatives were obtained by the reaction of these amino acids with o-phenylenediamine. N-Boc-chiral derivative of benzimidazoles were synthesized by inserting N-Boc amide derivatives into cyclization reaciton in an acidic environment. The synthesized N-Boc-chiral derivative of benzimidazoles were deprotected by reducing the protective group which was connected to amine group for obtaining chiral derivative of deprotected benzimidazoles. Then acetylated isothiocyanates were synthesized from 3 different monosaccharides (D-glucose, D-galactose, D-mannose). 12 original compounds (18-29) were obtained by the reaction of synthesized amide (4, 6, 8) and benzimidazole (12, 13, 14) compounds with isothiocynates. The products were characterized by spectroscopic methods (IR, 1H-NMR, 13C-NMR) and elemental analysis. Biological activities of the newly synthesized glycosyl thiourea derivative compounds were tested. | en_US |
| dc.description.abstract | Bu çalışmada, L-izolösin, D-fenilglisin, D-fenilalanin ve L-valin başlangıç amino asitleri olarak kullanıldı. Çalışmamızın ilk aşamasında, N-Boc-amino asit türevleri sentezlendi. Bu amino asitlerin o-fenilendiamin ile reaksiyonu sonucu amit türevleri elde edildi. N-Boc-kiral amit türevleri asidik ortamda halkalaşma reaksiyonuna sokularak N-Boc-kiral benzimidazol türevleri sentezlendi. Elde edilen N-Boc-kiral benzimidazol türevlerinin amin gruplarına bağlı olan koruyucu grup düşürülerek kiral benzimidazol türevleri elde edildi. Daha sonra üç farklı monosakkaritten (D-glukoz, D-galaktoz, D-mannoz) yola çıkarak asetillenmiş izotiyosiyanatlar sentezlendi. Sentezlenen amit (4, 6, 8) ve benzimidazol (12, 13, 14) bileşikleriyle izotiyosiyanatların reaksiyonu sonucu 12 adet (18-29) orjinal nitelikte yeni bileşik elde edildi. Ürünlerin yapıları spektroskopik yöntemlerle (IR, 1H-NMR, 13C-NMR) ve elementel analiz sonuçları ile karakterize edildi. Yeni sentezlenen glikozil tiyoüre türevi bileşiklerin biyolojik aktiviteleri test ettirildi. | en_US |
| dc.identifier.uri | https://hdl.handle.net/11454/59520 | |
| dc.language.iso | en | en_US |
| dc.publisher | Ege Üniversitesi, Fen Bilimleri Enstitüsü | en_US |
| dc.relation.publicationcategory | Tez | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Amide | en_US |
| dc.subject | Benzimidazole | en_US |
| dc.subject | Glycosyl Thiourea | en_US |
| dc.subject | Biological Activity | en_US |
| dc.subject | Amit | en_US |
| dc.subject | Benzimidazol | en_US |
| dc.subject | Glikozil İzotiyosiyanat | en_US |
| dc.subject | Biyolojik Aktivite | en_US |
| dc.title | Synthesis of thiourea and sugar derivatives of some chiral aromatic compounds and investigations of their biological activities | en_US |
| dc.title.alternative | Bazı kiral aromatik bileşiklerin tiyoüre ve şeker türevlerinin sentezi ve biyolojik aktivitelerinin incelenmesi | en_US |
| dc.type | Doctoral Thesis | en_US |
