Accumulation of 99tcm-polyclonal immunoglobulin in different stages of infection: An experimental study
Küçük Resim Yok
Tarih
1996
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this experimental study, the utility of 99Tcm-polyclonal human immunoglobulin (99Tcm-HIG) for localizing acute and chronic phases of inflammatory lesions was investigated. Three groups of rats were inoculated with Staphylococcus aureus in the right thigh. Then, 24 h (group I, n = 12), 48 h (group II, n = 12) and 72 h (group III, n = 12) post-inoculation, the rats received 40 MBq 99Tcm-HIG into the jugular vein. In addition, two control rats were studied at 24 h after inoculation of sterile saline. Both visual and quantitative evaluations were undertaken. The acute and chronic stages of inflammation were determined by pathological examination. The mean (±s.d.) lesion/contralateral uptake ratios at 4 and 24 h after 99Tcm-HIG injection were: group I,1.22 ± 0.1 and 2.12 ± 0.16; group II, 1.15 ± 0.08 and 2.25 ± 0.16; group III, 1.06 ± 0.09 and 2.08 ± 0.14. In conclusion, the acute and chronic phases of infection showed non-significant differences in 99Tcm-HIG uptake ratios. © 1996 Chapman and Hall Ltd.
Açıklama
Anahtar Kelimeler
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
17
Sayı
5
