Chemical constituents and biological activities of Dianthus elegans var. elegans

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dc.contributor.authorMutlu, Kiymet
dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorKirmizigul, Suheyla
dc.date.accessioned2019-10-27T10:44:34Z
dc.date.available2019-10-27T10:44:34Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractChemical investigation of the aerial parts of Dianthus elegans var. elegans afforded two previously undescribed saponins, named dianosides M-N (1-2), together with four oleanane-type triterpenoid glycosides (3-6). Their structures were elucidated as 3-O--L-arabinofuranosyl-16-hydroxyolean-12-ene-23, 28-dioic acid (1) and 3-O--L-arabinofuranosyl-(13)--D-glucopyranosyl 16-hydroxyolean-12-ene-23-oic acid, 28-O--D-glucopyranosyl-(16)--D-glycosyl ester (2) by chemical and extensive spectroscopic methods including IR, 1D, 2D NMR and HRESIMS. Both of the saponins were evaluated for their cytotoxicities against HEK-293, A-549 and HeLa human cancer cells using the MTT method. All compounds showed no substantial cytotoxic activity against tested cell lines. However, dianosides M-N and the n-butanol fraction exhibited considerable haemolysis in human erythrocyte cells. The immunomodulatory properties of dianosides M-N were also evaluated in activated whole blood cells by PMA plus ionomycin. Dianosides M-N increased IL-1 concentration significantly whereas the n-butanol fraction slightly augmented IL-1 secretion. All compounds did not change IL-2 and IFN- levels considerably. [GRAPHICS]en_US
dc.description.sponsorshipResearch Grant Office of Ege University Izmir-TurkeyEge University [2012 FEN 042]en_US
dc.description.sponsorshipThis research was supported by the Research Grant Office of Ege University Izmir-Turkey [grant number 2012 FEN 042].en_US
dc.identifier.doi10.1080/14786419.2017.1333988en_US
dc.identifier.endpage1253en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue11en_US
dc.identifier.pmid28587487en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1245en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2017.1333988
dc.identifier.urihttps://hdl.handle.net/11454/31004
dc.identifier.volume32en_US
dc.identifier.wosWOS:000430051100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaryophyllaceaeen_US
dc.subjectDianthus elegans varen_US
dc.subjectelegansen_US
dc.subjecttriterpenoid saponinen_US
dc.subjectcytotoxic activityen_US
dc.subjecthaemolytic activityen_US
dc.subjectimmunomodulatory activityen_US
dc.titleChemical constituents and biological activities of Dianthus elegans var. elegansen_US
dc.typeArticleen_US

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