Chemical constituents and biological activities of Dianthus elegans var. elegans
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Chemical investigation of the aerial parts of Dianthus elegans var. elegans afforded two previously undescribed saponins, named dianosides M-N (1-2), together with four oleanane-type triterpenoid glycosides (3-6). Their structures were elucidated as 3-O--L-arabinofuranosyl-16-hydroxyolean-12-ene-23, 28-dioic acid (1) and 3-O--L-arabinofuranosyl-(13)--D-glucopyranosyl 16-hydroxyolean-12-ene-23-oic acid, 28-O--D-glucopyranosyl-(16)--D-glycosyl ester (2) by chemical and extensive spectroscopic methods including IR, 1D, 2D NMR and HRESIMS. Both of the saponins were evaluated for their cytotoxicities against HEK-293, A-549 and HeLa human cancer cells using the MTT method. All compounds showed no substantial cytotoxic activity against tested cell lines. However, dianosides M-N and the n-butanol fraction exhibited considerable haemolysis in human erythrocyte cells. The immunomodulatory properties of dianosides M-N were also evaluated in activated whole blood cells by PMA plus ionomycin. Dianosides M-N increased IL-1 concentration significantly whereas the n-butanol fraction slightly augmented IL-1 secretion. All compounds did not change IL-2 and IFN- levels considerably. [GRAPHICS]
Açıklama
Anahtar Kelimeler
Caryophyllaceae, Dianthus elegans var, elegans, triterpenoid saponin, cytotoxic activity, haemolytic activity, immunomodulatory activity
Kaynak
Natural Product Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
32
Sayı
11
