Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure

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dc.contributor.authorBilgin, Murat
dc.contributor.authorYildiz, Bekir Serhat
dc.contributor.authorTuluce, Kamil
dc.contributor.authorGul, Ilker
dc.contributor.authorAlkan, Mustafa Beyazit
dc.contributor.authorSayin, Ahmet
dc.contributor.authorIslamli, Aysel
dc.contributor.authorEfe, Tolga Han
dc.contributor.authorAlihanoglu, Yusuf Izzettin
dc.contributor.authorZoghi, Mehdi
dc.contributor.authorAkin, Mustafa
dc.date.accessioned2019-10-27T23:09:01Z
dc.date.available2019-10-27T23:09:01Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Atrial functions are relatively suppressed in heart failure (HF). We aimed to investigate the associations of intra-and inter-atrial electromechanical conduction delay (EMCD) with functional class and mortality over a 12-month follow-up period. Methods: The prospective study included 65 patients with systolic HF and 65 healthy subjects with normal sinus rhythm. Left ventricular (LV) systolic functions and left atrial (LA) dimensions and volumes were evaluated by transthoracic echocardiography. Tissue Doppler imaging (TDI) signals at the lateral border of the mitral annulus (lateral PA'), septal mitral annulus (septal PA'), and tricuspid annulus (tricuspid PA') were measured. Intra-and inter-atrial EMCD were calculated. Results: Mitral inflow velocities were studied using pulsed-wave Doppler after placing the sample volume at the leaflets' tips. The peak early (E wave) and late (A wave) velocities were measured. The septal annular E/E' ratio was relatively higher and lateral, septal, and right ventricular S,E', and A' waves were significantly lower in the HF group than in the control group (12.49 +/- 6.03-7.16 +/- 1.75, pE/E' <0.0001). Intra-atrial EMCD was detected as 117.5 ms and inter-atrial EMCD as 127.5 ms in patients with prolonged atrial EMCD. A significant increase was found in prolonged intra-and inter-atrial EMCD according to functional capacity increase (p=0.012 and p=0.031, respectively). The incidence of mortality was significantly higher in patients with prolonged atrial EMCD (p=0.025), and 5 patients in the HF group died during the study over the 12-month follow-up period. Conclusions: In this study, we found a relationship between prolonged atrial conduction time and increased functional class and mortality in patients with systolic HF.en_US
dc.identifier.doi10.5152/AnatolJCardiol.2015.6445
dc.identifier.endpage586en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue8en_US
dc.identifier.pmid27004707en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.5152/AnatolJCardiol.2015.6445
dc.identifier.urihttps://hdl.handle.net/11454/52478
dc.identifier.volume16en_US
dc.identifier.wosWOS:000384427500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectheart failureen_US
dc.subjectatrial electromechanical delayen_US
dc.subjectfunctional classen_US
dc.subjectmortalityen_US
dc.titleEvaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failureen_US
dc.typeArticleen_US

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