Predictive value of proliferating cell nuclear antigen index in response to interferon treatment in patients with chronic viral hepatitis B and C

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dc.contributor.authorKarasu Z.
dc.contributor.authorYilmaz F.
dc.contributor.authorErsöz G.
dc.contributor.authorGünşar F.
dc.contributor.authorBatur Y.
dc.contributor.authorAkarca U.S.
dc.date.accessioned2019-10-27T00:25:15Z
dc.date.available2019-10-27T00:25:15Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aims: There are several parameters which may predict the response to interferon therapy in patients with chronic hepatitis B and chronic hepatitis C. The aim of this study was to evaluate the predictive value of proliferating cell nuclear antigen index (PCAN-i) in determining the response rate to interferon therapy in patients with these infections. Methods: Twenty-three patients with chronic hepatitis B and 27 with chronic hepatitis C were included in the study. Prior to therapy, liver biopsies were evaluated with respect to Knodell's index and PCNA-i. Results: Histologic activity indices of the patients with chronic hepatitis B and chronic hepatitis C were similar, but the patients with chronic hepatitis B had higher PCNA-i compared to those with chronic hepatitis C (15.4±5.5 vs 11.3±5.0, p=0.009). PCNA-i was significantly lower in non-responders than responders in the chronic hepatitis B group, whereas responders tended to have lower PCNA-i values in patients with chronic hepatitis C. Conclusions: Responders with chronic hepatitis B had elevated PCNA-i, while the patients with chronic hepatitis C who responded to interferon therapy tended to have lower PCNA-i but the reason for that difference is not clear. According to these results PCNA-i may be used as a predictive marker for the response to interferon therapy in patients with chronic hepatitis B.en_US
dc.identifier.endpage94en_US
dc.identifier.issn1300-4948
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://hdl.handle.net/11454/23219
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic hepatitis Ben_US
dc.subjectChronic hepatitis Cen_US
dc.subjectInterferonen_US
dc.subjectPCNAen_US
dc.titlePredictive value of proliferating cell nuclear antigen index in response to interferon treatment in patients with chronic viral hepatitis B and Cen_US
dc.typeArticleen_US

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