Predictive value of proliferating cell nuclear antigen index in response to interferon treatment in patients with chronic viral hepatitis B and C
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/aims: There are several parameters which may predict the response to interferon therapy in patients with chronic hepatitis B and chronic hepatitis C. The aim of this study was to evaluate the predictive value of proliferating cell nuclear antigen index (PCAN-i) in determining the response rate to interferon therapy in patients with these infections. Methods: Twenty-three patients with chronic hepatitis B and 27 with chronic hepatitis C were included in the study. Prior to therapy, liver biopsies were evaluated with respect to Knodell's index and PCNA-i. Results: Histologic activity indices of the patients with chronic hepatitis B and chronic hepatitis C were similar, but the patients with chronic hepatitis B had higher PCNA-i compared to those with chronic hepatitis C (15.4±5.5 vs 11.3±5.0, p=0.009). PCNA-i was significantly lower in non-responders than responders in the chronic hepatitis B group, whereas responders tended to have lower PCNA-i values in patients with chronic hepatitis C. Conclusions: Responders with chronic hepatitis B had elevated PCNA-i, while the patients with chronic hepatitis C who responded to interferon therapy tended to have lower PCNA-i but the reason for that difference is not clear. According to these results PCNA-i may be used as a predictive marker for the response to interferon therapy in patients with chronic hepatitis B.
Açıklama
Anahtar Kelimeler
Chronic hepatitis B, Chronic hepatitis C, Interferon, PCNA
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
12
Sayı
2
