The Effect of Botulinum Toxin on Flap Viability of the Posterior Thigh Perforator Flap in Rats

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dc.contributor.authorErdem, Mehmet
dc.contributor.authorTiftikcioglu, Yigit
dc.contributor.authorTatar, Burak Ergun
dc.contributor.authorKilic, Kubilay Dogan
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorGurler, Tahir
dc.date.accessioned2021-05-03T20:21:25Z
dc.date.available2021-05-03T20:21:25Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The use of perforator propeller flaps in lower limb reconstruction has increased recently. Many pharmacological agents are used to increase flap viability. Botulinum toxin has been used in various types of flaps in the literature. However, there is no study regarding the use of botulinum toxin in the lower limb propeller flaps. This study investigates the effect of botulinum toxin administration on flap survival for lower limb propeller flap in rats. Materials and methods: The study included 20 male Wistar albino rats, divided into two groups with a flap rotation of 90 degrees in group 1 and 180 degrees in group 2. in both groups, botulinum toxin was administered to the right thigh and a physiological saline solution was applied to the left thigh. Five days later, flaps were elevated over the posterior aspect of the right and left thighs and inset after 90 degrees and 180 degrees rotation was performed. Histopathological, immunohistochemical, and necrosis area analyses were performed. Results: Necrosis area, edema, polymorphonuclear leukocyte infiltration, and necrosis were found to be higher on the left side of the groups, whereas epidermal thickness, collagen density, vascularization, and hair root density were found to be higher on the right side of the groups. No significant difference was found between the right posterior thighs in either group on any parameter other than vascularization. Histopathologically and immunochemically statistically significant differences were found between the two groups. Conclusions: The present study found that botulinum toxin increases flap viability in lower limb perforator-based propeller flaps. (C) 2020 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2020.12.025en_US
dc.identifier.endpage94en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.pmid33422903en_US
dc.identifier.scopus2-s2.0-85098793343en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2020.12.025
dc.identifier.urihttps://hdl.handle.net/11454/69316
dc.identifier.volume261en_US
dc.identifier.wosWOS:000635161100012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLower extremity reconstructionen_US
dc.subjectPropeller flapen_US
dc.subjectMicrosurgeryen_US
dc.titleThe Effect of Botulinum Toxin on Flap Viability of the Posterior Thigh Perforator Flap in Ratsen_US
dc.typeArticleen_US

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