The Effect of Botulinum Toxin on Flap Viability of the Posterior Thigh Perforator Flap in Rats
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Inc Elsevier Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The use of perforator propeller flaps in lower limb reconstruction has increased recently. Many pharmacological agents are used to increase flap viability. Botulinum toxin has been used in various types of flaps in the literature. However, there is no study regarding the use of botulinum toxin in the lower limb propeller flaps. This study investigates the effect of botulinum toxin administration on flap survival for lower limb propeller flap in rats. Materials and methods: The study included 20 male Wistar albino rats, divided into two groups with a flap rotation of 90 degrees in group 1 and 180 degrees in group 2. in both groups, botulinum toxin was administered to the right thigh and a physiological saline solution was applied to the left thigh. Five days later, flaps were elevated over the posterior aspect of the right and left thighs and inset after 90 degrees and 180 degrees rotation was performed. Histopathological, immunohistochemical, and necrosis area analyses were performed. Results: Necrosis area, edema, polymorphonuclear leukocyte infiltration, and necrosis were found to be higher on the left side of the groups, whereas epidermal thickness, collagen density, vascularization, and hair root density were found to be higher on the right side of the groups. No significant difference was found between the right posterior thighs in either group on any parameter other than vascularization. Histopathologically and immunochemically statistically significant differences were found between the two groups. Conclusions: The present study found that botulinum toxin increases flap viability in lower limb perforator-based propeller flaps. (C) 2020 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Lower extremity reconstruction, Propeller flap, Microsurgery
Kaynak
Journal of Surgical Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
261
