The effects of different intraabdominal pressure protocols in laparoscopic procedures on oxidative stress markers and morphology in rat ovaries

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dc.contributor.authorBiler A.
dc.contributor.authorYucebilgin S.
dc.contributor.authorSendag F.
dc.contributor.authorAkman L.
dc.contributor.authorAkdemir A.
dc.contributor.authorAtes U.
dc.contributor.authorUyanikgil Y.
dc.contributor.authorYilmaz-Dilsiz O.
dc.contributor.authorSezer E.
dc.date.accessioned2019-10-27T08:21:41Z
dc.date.available2019-10-27T08:21:41Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: To determine the effects of different intraabdominal pressure (IAP) on the ovaries in a laparoscopic rat model. Objectives: The aim of the study was to determine the effects on the ovaries of different intraabdominal pressures (IAP) in laparoscopic surgery in a rat model. Material and Methods: Thirty-two post-pubertal nonpregnant Sprague-Dawley rats were divided randomly into four groups. In the control group, no intraabdominal pressure (IAP) was applied. In Group Pp10 and Group Ppl5, an IAP of 10 and 15 mm Hg, respectively, were applied by carbon dioxide insufflation for 60 min, and a 30-min desufflation was carried out. In Group IPp15, a 15 mm Hg IAP was applied for 10 min, and then CO2 was desufflated for 10 min. After this ischemic preconditioning, IAP was established at 15 mm Hg for 60 min, after which CO2 was desufflated for 30 min. Erythrocyte and ovarian tissue malondialdehyde (MDA) and histopathologic damage scores were evaluated. Results: In Groups Pp10 and Ppl5, ovarian tissue MDA values were significantly increased compared to the control group. In Groups Pp10 and Pp15, erythrocyte MDA values were significantly increased when compared to Group IPp15 and the control group. Ovarian histopatological assesment scores were significantly higher in Group Ppl5 than in Groups Pp10 and IPp15. Conclusions: Pneumoperitoneum causes injuries to abdominal organ such as the ovaries. The ischemic preconditioning method is more effective in reducing oxidative stress due to laparoscopic pneumoperitoneum than lowpressure pneumoperitoneum methods.en_US
dc.identifier.doi10.17219/acem/37331en_US
dc.identifier.endpage892en_US
dc.identifier.issn1899-5276
dc.identifier.issue6en_US
dc.identifier.pmid25618113en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage885en_US
dc.identifier.urihttps://doi.org/10.17219/acem/37331
dc.identifier.urihttps://hdl.handle.net/11454/26086
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw University of Medicineen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemic preconditioningen_US
dc.subjectLaparoscopyen_US
dc.subjectOxidative stressen_US
dc.subjectPneumoperitoneumen_US
dc.subjectReperfusionen_US
dc.titleThe effects of different intraabdominal pressure protocols in laparoscopic procedures on oxidative stress markers and morphology in rat ovariesen_US
dc.typeArticleen_US

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