Management of Childhood Thyroid Nodules: Surgical and Endocrinological Findings in a Large Group of Cases

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dc.contributor.authorDivarci, Emre
dc.contributor.authorCeltik, Ulgen
dc.contributor.authorDokumcu, Zafer
dc.contributor.authorErgun, Orkan
dc.contributor.authorOzok, Geylani
dc.contributor.authorOzen, Samim
dc.contributor.authorSimsek, Damla Goksen
dc.contributor.authorDarcan, Sukran
dc.contributor.authorCetingul, Nazan
dc.contributor.authorOral, Aylin
dc.contributor.authorErtan, Yesim
dc.contributor.authorDemirag, Bengu
dc.contributor.authorCelik, Ahmet
dc.date.accessioned2019-10-27T11:06:03Z
dc.date.available2019-10-27T11:06:03Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred pediatric cases. Methods: A retrospective analysis of patients admitted with a thyroid nodule between 2006 and 2014 was performed. Detailed ultrasonography and fine-needle aspiration biopsy (FNAB) were the cornerstones of the diagnostic approach. Results: One hundred-three children (72 female, 31 male) with a mean age of 13.1 +/- 3.6 years (3-18 years) were admitted to our center. Management strategy was surgery in 58 patients and follow-up in 45 patients. Mean nodule size was 17 +/- 12.7 mm (2-45 mm). The diagnoses were listed as benign solitary nodule (48 patients), thyroid carcinoma (26 patients), multinodular goiter (23 patients), Hashimoto thyroiditis (4 patients), and Graves' disease (2 patients). Surgical procedures were nodulectomy/lobectomy (32 patients), total thyroidectomy (TT) (13 patients), or TT+ neck dissection (13 patients). The rate of malignancy was 25% in the total group and 44% in the surgery group. The malignancy rate was higher in patients younger than 12 years compared to older children (41% vs. 17%, p = 0.040). Metastasis was seen in 38% of the malignant nodules. Postoperative complications were transient hypocalcemia (8%), permanent hypocalcemia (1.7%), and unilateral vocal cord paralysis (1.7%). Recurrence or mortality was not encountered in the 5.4 +/- 1.2-year follow-up period. Conclusion: Thyroid nodule in a child requires an aggressive diagnostic approach due to increased risk of malignancy and metastasis. Intraoperative frozen section examination must be done as a useful adjunct to determine the surgical strategy. Incidence of complications is small in thyroid surgery when performed by experienced surgeons.en_US
dc.identifier.doi10.4274/jcrpe.4272
dc.identifier.endpage228en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue3en_US
dc.identifier.pmid28387647en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.4272
dc.identifier.urihttps://hdl.handle.net/11454/31783
dc.identifier.volume9en_US
dc.identifier.wosWOS:000410406300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid noduleen_US
dc.subjectthyroidectomyen_US
dc.subjectpapillary carcinomaen_US
dc.subjectfrozen sectionen_US
dc.subjectfine-needle aspiration biopsyen_US
dc.titleManagement of Childhood Thyroid Nodules: Surgical and Endocrinological Findings in a Large Group of Casesen_US
dc.typeArticleen_US

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